PK - Vancomycin & Aminoglycosides

Vancomycin & Aminoglycoside Pharmacokinetics

Patient Information :

Drug : Calculation :

Drug Dose : Dosing Interval :

Drug Infusion Time :

Current Weight : Admit Weight :

Gender :

Age : years Serum Creatinine : mg/dL

Height :
inches Vancomycin Clearance :

Serum Peak : mg/L Time Peak Drawn : hrs

Serum Trough : mg/L Time Trough Drawn : hrs

Ideal Body Weight : Creatinine Clearance :

Vancomycin Clearance :

Vd : Kel :

t_½ :

Revised Cl : Revised Vd :

Revised k : Revised t ½ :

Select Dosing Interval ( t ) :

� ( usu. ≥2 x t ½ )

( i.e. q8º, q12º )
Select target peak : mg/L

Select Dosing Interval ( t ) :

� ( usu. 1-2 x t ½ )

( i.e. q12º, q24º )
Select target trough : mg/L

New Dose : Round Dose :

New Estimated Peak :
after end of infusion New Estimated Trough :

References :
Young, Lloyd Y., and Koda-Kimble, Mary A. Applied Therapeutics: The Clinical Use of Drugs. 6th Edition. Vancouver: Applied Therapeutics, Inc., 1995.
Equations :
Initial Bolus-Model Equations
Initial Short-Infusion Equations
Revision Bolus-Model Equations
Revision Short-Infusion Equations