Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)
kel =
ln(
Cpss (peak)
Cpss (trough)
)
D
t
Cl (L/hr) =
Dose
( 1 - e
- kt
in
) x e
-
kt
Cpss x t
in
( 1 - e
- k
t
)
Dose (mg) =
Cp
ss
x Cl x t
in
x ( 1 - e
- k
t
)
( 1 - e
- kt
in
) ( e
- kt
)
Cp
ss
max (mg/L) =
Dose
( 1 - e
- kt
in
) x e
- kt
1
t
in
x Cl
( 1 - e
- k
t
)
Cp
ss
min (mg/L) =
Dose
( 1 - e
- kt
in
) x e
- kt
2
t
in
x Cl
( 1 - e
- k
t
)
